S.H.I.E.L.D.'s battle with Hydra comes to a head, leading to the death of a key player. Plus, what is Operation Brain Blast? S.H.I.E.L.D. delves into the realm of the supernatural with a new ESP division. Will Fury become the first unwilling subject? Doctor Strange reaches an agreement with Dormammu. Clea is banished to a much darker dimension.